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Literature References

1. Garcia-Olmo D, Garcia-Arranz M, et al. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 2005 Jul;48(7): 1416-23.

2. Bang OY, Lee JS, Lee PH, et al. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005 Jun;57(6):874-82.

3. Harman R, Cowles B, Orava C, et al. A retrospective review of 60 cases of joint injury in sport horses treated with adipose derived stem and regenerative cell therapy. Vet Stem internal data, 2006.

4. Harman R, Cowles B, Orava C., et al. A retrospective review of 52 cases of suspensory ligament injury in sport horses treated with adipose-derived stem and regenerative cell therapy. Presented at the Veterinary Orthopedic Society Convention Mar 3-10, 2007 in Sun Valley, ID.

5. Nixon A, Dahlgren L. Adipose-Derived Pluripotent Stem Cells for Tendon Repair. Submitted to Equine Vet J, 2006.

6. VetStem Biopharma, Data on file.

7. Murphy JM, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003 Dec;48(12):3464-74.

8. Nathan S, Das De S, Thambyah A, et al. Cell-based therapy in the repair of osteochondral defects: A novel use for adipose tissue. Tissue Eng 2003 Aug;9(4):733-44.

9. Awad HA, Butler DL, et al. Autologous mesenchymal stem cell-mediated repair of tendon. Tissue Eng 1999 Jun:5(3):267-77.

10. Bruder SP, Kraus KH, Goldberg VM, et al. The effects of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 1998 Jul:80(7):985-96.

11. Bruder SP, Jaiswal N, Kadiyala S, et al. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res 1998 Oct:355 Suppl:S247-56.

12. Cowan CM, Shi YY, Aalami OO, et al. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol 2004 May;22(5):560-7.

13. Jeong JH, Ki YW, Kim JY, Jan SH, Kim SH, Chang Y. Adipose Tissue Derived MSC Enhances Motor Function in Rats with Cerebral InfARCtion. IFATS 2005. Oral Presentation.

14. Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001; 32: 1005-1011

15. Luyten FP. Mesenchymal stem cells in osteoarthritis. Curr Opin Rheumatol 2004 Sep;16(5):599-603.

16. Strem BM, Hicok KC, Zhu M, Wulur I, Alfonso Z, Schreiber RE, Fraser JK, Hedrick MH. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med 2005 Sep;54(3):132-41.

17. Assmus B, Schachinger V, Teupe C, et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 2002 Dec 10;106(24):3009-17.

18. Herreros J, Prosper F, Perez A, et al. Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur Heart J 2003 Nov;24(22):2012-20.

19. El-Badri NS, Maheshwari A, Sanberg PR. Mesenchymal stem cells in autoimmune disease. Stem Cells Dev 2004 Oct;13(5):463-72.

20. Pluchino S, Martino G. The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disorders. J Neurol Sci 2005 Jun 15;233(1-2):117-9.

21. Uccelli A, Zappia E, Benvenuto F, et al. Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotection. Expert Opin Biol Ther 2006 Jan;6(1):17-22.

22. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002 Dec;13(12):4279-95

23. Oedayrajsingh M, Breuls R, Schouten T, et al. Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cells Dev 2007;16:91-104.

24. Fraser JK, Wulur I, Alfonso Z, et al. Fat Tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol 2006 Apr;24(4):150-4.

25. Nakagami H, Morishita R, Maeda K, et al. Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. J Atheroscler Throm 2006 Apr;13(2):77-81.

26. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005 Feb 15;105(4):1815-22.

27. Potian JA, Aviv H, Ponzio NM, Harrison JS, Rameshwar P.. Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol. 2003 Oct 1;171(7):3426-34.

28. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV, MARCh KL. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004 Mar 16;109(10):1292-8.

29. Parker A, Katz A. Adipose-derived stem cells for the regeneration of damaged tissues. Expert Opin Biol Ther 2006;6(6):567-578.

30. Yanez R, Lamana ML, Garcia-Castro J, et al. Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease (GVHD). Stem Cells Aug. 24, 2006 Online version.

31. Lendeckel S, Jodicke A, Christophis P, et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomax Surg 2004;32(6):370-373.

32. Nilsson, S.K. et al.1999. Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J. Exp. Med. 189:729-734.

33. Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, Lu M, Zhu Z, Chopp M. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003 Apr 4;92(6):692-9.

34. Miranville A, Heeschen C, Sengenes C, Curat CA, Busse R, Bouloumie A. Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation. 2004 Jul 20;110(3):349-55.

35. Bjelakovic G, Nagorni A, Bjelokovic M, Stamenkovic I, Arsic R, Katic V. Apoptosis: programmed cell death and its clinical implications. Medicine and Biology Vol.12, No 1, 2005, pp. 6 - 11

36. Kortesidis A, Zannettino A, Isenmann S, Shi S, Lapidot T, Gronthos S.Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood. 2005 May 15;105(10):3793-801.

37. Harman R, Cowles B, Orava C, et al. A retrospective study of 66 cases of tendon injury in the equine treated with adipose-derived stem and regenerative cell therapy. Vet Stem internal data, 2006.


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