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What is VetStem Regenerative Medicine? (cont.)

Trophic Support:
Multiple studies demonstrate that MSCs secrete bioactive levels of cytokines and growth factors that that support angiogenesis, tissue remodeling, differentiation, and antiapoptotic events. 25,28 MSCs secrete a number of angiogenesis-related cytokines such as:28
Differentiation:
Adipose derived MSC studies demonstrate a diverse plasticity, including differentiation into adipo-, osteo-, chondro-, myo-, cardiomyo-, endothelial, hepato-, neuro-, epithelial and hematopoietic lineages, similar to that described for bone marrow derived MSC. 22  These data are supported by in vivo experiments and functional studies that demonstrated the regenerative capacity of adipose-derived MSCs  to repair damaged or diseased tissue via transplant engraftment and differentiation. 6,9,30 
Homing:
Homing (chemotaxis) is an event by which a cell migrates from one area of the body to a distant site where it may be needed for a given physiological event.  Homing is an important function of MSCs and other progenitor cells and one mechanism by which intravenous or parenteral administration of MSCs permits an auto-transplanted therapeutic cell to effectively target a specific area of pathology.
Revascularization:
Adipose derived regenerative cells contain endothelial progenitor cells and MSCs that assist in angiogenesis and neovascularization by the secretion of cytokines, such as hepatic growth factor (HGF), vascular endothelial growth factor (VEGF), placental growth factor (PGF), transforming growth factor (TGFβ), fibroblast growth factor (FGF-2), and angiopoietin.25
Anti -Apoptosis:
Apoptosis is defined as a programmed cell death or “cell suicide”, an event that is genetically controlled.35  Under normal conditions, apoptosis determines the lifespan and coordinated removal of cells.  Unlike necrosis, apoptotic cells are typically intact during their removal (phagocytosis). 
  • Kortesidis and colleagues also demonstrate that MSCs express factors that support cell survival and avoid apoptosis thereby preserving cells that would otherwise be destroyed.36



Literature References
Literature references and abstracts for regenerative stem cell technology. >LEARN MORE

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DEMONSTRATED EFFICACY OF REGENERATIVE CELL THERAPY
Human clinical trials:

  • Crohn's fistula1
  • Stroke2
Ongoing human clinical trials:
  • Advanced heart failure
  • Heart bypass surgical trial
  • Osteoarthritis
  • Fractures
  • Arthritis
  • Liver disease
  • Renal disease
Animal models of disease:
  • Osteoarthritis7, 15
  • Osteochondral defects8
  • Tendon repair5,9
  • Fractures10-12
  • Cerebral infarction13-14
  • Myocardial infarction16-18
  • Muscular dystrophy16
  • Autoimmune disorders19-21
 


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